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0.5.5e
An upfront cost is one that lists just an amount of resource to pay, rather than a per-second rate to pay at. "3 Mana" is an Upfront Cost, while "3 Mana per second" is not.
Your flesh has been tainted. You reserve life equal to the upfront cost of skills.
Your soul has been tainted. You reserve mana equal to the upfront cost of skills.